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Tapentadol is an opioid therapy for moderate to severe pain. Nucynta ER is the extended-release form for treating pain 24 hours a day that is not checked by other medicines. This tapentadol form is not suitable for pain on a necessary basis. For purposes not listed in this medication guide, tapentadol may also be used. How Should Tapentadol Be Used? Tapentadol is available as a tablet and an extended-release tablet to be taken by mouth. Usually, every 4 to 6 hours, the tablets are taken with or without food. If you take tapentadol tablets, your doctor will tell you to take a second dose, if required to treat your pain, as soon as one hour after your first dose on the first day of your treatment. Do not take any additional doses at any other time during your treatment and do not take any additional doses. Every 12 hours, the extended frequency tablets are taken. Follow your prescription label carefully to explain any part you don't know to your doctor or pharmacist. As directed,